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Thoracic outlet compression syndrome

  • Describes a collection of upper limb neurological and vascular symptoms
  • Arise from proximal compression of neurovascular structures
  • Usually affects middle aged women
  • Male : female ratio is  1:3
  • 10% have bilateral symptoms

Pathophysiology

  • Compression can result from a bone, muscle or fibromuscular band
  • Compressing lesion is usually congenital
  • 30% of cases follow trauma (e.g. whiplash injury)

Causes of thoracic outlet compression syndrome

Clinical features

  • Neurological features are more common than vascular
  • Subclavian artery aneurysm and axillary vein thrombosis are uncommon
  • Symptoms often worsened by carrying weights or lifting arms above head
  • Differential diagnosis includes:
    • Cervical spondylosis
    • Distal nerve compression
    • Pancoast's tumour
    • Connective tissue disorders
    • Vascular and venous embolic disease
  • Diagnosis depends mainly on the history
  • Signs are few but diagnosis may be confirmed with the
    • Roos test - Reproduction of symptoms with arms flexed and abducted
    • Subclavian compression tests (e.g. Adson's manoeuvre)
    • Loss of radial pulse with head turned to opposite side and neck extended

Investigations

  • The results of investigations are often normal
  • A CXR may show a cervical rib
  • Nerve conduction studies may be needed to exclude a distal nerve compression
  • Arch aortogram may show a subclavian artery aneurysm
  • Duplex scanning may show arterial or venous compression and the effect of position

Chest x-ray showing a cervical rib

Picture provided by Andrew McIrvine, Darent Valley Hospital, Dartford, United Kingdom

Treatment

  • Symptoms may improve with physiotherapy
  • If disabling symptoms need to consider surgical decompression
  • Involves resection of most of first rib
  • Can be achieved through either a supraclavicular or transaxillary approach
  • 10% will develop a pneumothorax

Prognosis

  • 80% report a symptomatic improvement
  • More than 50% of patients are usually symptom free
  • Failure to improve is often due to:
    • A double crush compression syndrome
    • Incomplete division of compressing structure

Bibliography

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