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Multiple endocrine neoplasia syndromes

MEN 1  Syndrome (Wermer's Syndrome)

Hyperparathyroidism 90%
Pancreatic Islet Cell Tumours 60%
Gastrinoma 60%
Insulinoma 10%
Vipoma
PPoma
Glucagonoma
Pituitary Tumours 5%
Prolactinoma
GH, ACTH, TSH secreting tumours
Thyroid adenoma
Adrenal adenoma
Carcinoid tumours

MEN 2a Syndrome (Sipple's Syndrome)

Medullary Thyroid Carcinoma 100%
Phaeochromocytoma 50%
Hyperparathyroidism 10%

MEN 2b Syndrome

Medullary Thyroid Carcinoma 100%
Phaeochromocytoma 50%
Multiple mucosal neuromas 100%
Ganglioneuromatosis of the gut 100%
Marfanoid appearance 100%>

Bibliography

Aldridge M C.  Islet cell tumours:  surgical management.  Hosp Med 2000;  61:  830-833.

Learoyd D L,  Delbridge L W,  Robinson B G.  Multiple endocrine neoplasia.  Aust NZ J Med 2000;  30:  75-82.

Mullen M H,  Gauger P G,  Thompson N W.  Endocrine tumours of the pancreas: review and recent advances.  Aust NZ J Surg 2001;  71:  754-482.

Play J E,  Moley J F,  Lairmore T C.  Multiple endocrine neoplasias.  Semin Surg Oncol 2000;  18:  328-332.

Proye C A,  Nguyen H H.  Current perspective in the surgery for multiple endocrine neoplasias.  Aust NZ J Surg 1999;  69:  106-116.

Taheri S,  Meeran K.  Islet cell tumours.  diagnosis and medical management.  Hosp Med 2000;  61:  824-829.

 

 
 

Last updated: 05 January 2008

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